The story behind Bomarzo and the life of Pier Francesco Orsini are the subject of a novel by the Argentinian writer Manuel Mujica Láinez (1910–1984), Bomarzo (1962).
Based on a novel by Graham Greene, the film tells the story of a man just released from a mental asylum who finds himself caught up in an international spy ring and pursued by foreign agents after inadvertently receiving something they want.