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William married before 19 June 1602 Lettice Knollys (1583–1655), daughter of Sir Henry Knollys (c. 1542 - 1583), Member of Parliament representing first Shoreham, Kent (1563) and then Oxfordshire, Esquire of the Body to Elizabeth I (son of Sir Francis Knollys and Catherine Carey), and Margaret Cave (1549–1600), daughter of Sir Ambrose Cave and Margaret Willington.