Nichols' may be best known for his collaboration with Hagar Wilde on the screenplay for Bringing Up Baby (1938), often considered one of the funniest of the 1930s screwball comedies.
Her work includes co-writing the screenplay for Bringing Up Baby (for which she had also written the original story, published in the mass-market magazine Collier's Weekly), starring Katharine Hepburn and Cary Grant, and was directed by Howard Hawks, and the screenplay for I Was a Male War Bride, also starring Cary Grant and again directed by Howard Hawks as well as co-wrote The Unseen.
However, the disastrous reception of Bringing Up Baby led to Hepburn being considered "box office poison" and Lombard being cast instead.
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In It Happened One Night and Bringing up Baby both females leads are of high social status and fall in love with males of lower social economic status then themselves.
She featured as a mentor in the 2007 Channel 4 documentary series, Bringing Up Baby (which compared the 1950s Truby King method with the 1960s Benjamin Spock and the 1970s Continuum concept).
In 2007, she wrote to the National Society for the Prevention of Cruelty to Children and accused fellow child-care expert Claire Verity of “child abuse” for methods used in a Channel 4 series called Bringing Up Baby.