Krause then began a career in the Argentine railways, working in the planning department of the Buenos Aires Western Railway in 1879 and later contributing to the lines' extension into then-remote Tucumán and Salta Provinces.
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Named President of the newly established Buenos Aires Western Railway, he presided over the August 30, 1857, inaugural of its first line, designed by British engineer William Bragge.
He established a national mint under the auspices of the Bank of the Province of Buenos Aires, and subsidies for industry and commerce; on August 30, 1857, the recently established Buenos Aires Western Railway inaugurated its first line, designed by British engineer William Bragge.