From 1918-53, he was professor and chairman of the Dept. of Physiology at Western Reserve University Medical School that became known as Case Western Reserve University School of Medicine.
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After graduation Heymans worked at the Collège de France (under Prof. E. Gley), the University of Lausanne (under Prof. M. Arthus), the University of Vienna (under Prof. H. H. Meyer), University College London (under Prof. E. H. Starling) and Case Western Reserve University School of Medicine (under Prof. C. F. Wiggers).