One of its more notable inhabitants was Catherine, Duchess of Queensberry.
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After his death in 1725, Carlton's nephew, Charles Douglas, 3rd Duke of Queensberry inherited the house and, with his wife, Catherine "Kitty" Hyde, the couple played host to literary and artistic figures of the time including John Gay who is reputed to have written and rehearsed the Beggar's Opera in 1728 whilst at the riverside summerhouse in the grounds.