Essenhigh's work attracted attention as one of a generation of young painters in New York in the late 1990s, including Cecily Brown, Damien Loeb and Will Cotton.
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He shifted the focus to exhibitions of contemporary artists, who have included Cecily Brown, Jake and Dinos Chapman, Tracey Emin, Gary Hume, Daniel Buren, Stella Vine, Sol LeWitt and Kerry James Marshall.