In 1496 the Aragonese were besieged by the French under King Charles VIII, who destroyed the castle and executed the nobles of Acri by sawing them alive.
However, in 1495 the city fell to the French under Charles VIII, and he fled east to the Ottoman Empire to escape the violent pogroms that ensued, spending time in Istanbul before moving sometime between 1498 and 1504 to teach Torah in Salonica, at that time in a state of intellectual vibrancy due to the settlement there of many Sephardi exiles forced to leave after the expulsion of the Jews from Spain in 1492, Sicily in 1493, and Portugal in 1496.
It is especially remembered as the seat of the Battle of Fornovo, fought in 1495 between the Italian league and the French troops of Charles VIII.
In 1495, he fought in Italy on behalf of king Charles VIII of France, (- king 1483 - 1498), disputing Naples to the Spaniards getting then under the service of Cesare Borgia, (1475 - killed March 1507, at Viana, Navarre, now in Spain) .
In 1497 it was sacked by the troops of Charles VIII of France, and the fief went to Artusio Pappacoda, whose family held it for a century and a half.
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Alain the Great, lord of Albret (d. 1522), wished to marry Anne of Brittany, and to that end fought against Charles VIII; but his hopes being defeated by the betrothal of Anne to Maximilian of Austria, he surrendered Nantes to the French in 1486.
After the death of Charles the Bold, who in his youth had borne the title of count of Charolais, it was seized by Louis XI of France, but in 1493 it was ceded by Charles VIII to Maximilian of Austria, the representative of the Burgundian family.
Built by Hugues d'Amboise in the middle of the fifteenth century, it was acquired in 1490 by Charles VIII of France for his wife, Anne de Bretagne.
He was made the Viceroy of Naples in 1495 by king Charles VIII of France after the conquest, losing it that same year to an allied Neapolitan/Spanish army commanded by Gonzalo Fernández de Córdoba.
He fought as one of Pope Alexander VI's captains alongside the French troops of King Charles VIII of France during the latter's invasion of southern Italy; later, he was hired by the Republic of Venice against Charles.
A combination of King Louis XII of France and King Ferdinand II of Aragon had continued the claim of Louis' predecessor, King Charles VIII of France, to Naples and Sicily.
Designed and supervised elaborate theatrical spectacles for Charles VIII of France and Anne of Brittany's ceremonial entry into Tours following their marriage (of 6 December 1491).
He was a descendant of Denis d'Envrich, who fought in the Battle of Fornoue in 1495 and was bestowed the name of LeBreton by Charles VIII of France.
He visited France again on diplomatic business on 30 November 1477, and on 11 August 1478, to conclude the espousals of Edward's daughter Elizabeth and Charles, son of the French king.