Chromosomal crossover | chromosomal crossover | Species translocation | Robertsonian translocation | chromosomal rearrangement |
ALK inhibitors are potential anti-cancer drugs that act on tumours with variations of anaplastic lymphoma kinase (ALK) such as an EML4-ALK translocation.
Mutations associated with papillary thyroid cancer are mainly two forms of chromosomal translocation and one form of point mutation.
Tyrosine kinase inhibitors such as imatinib (marketed as Gleevec) have been developed to treat chronic myeloid leukemia (CML), in which the BCR-ABL fusion gene (the product of a reciprocal translocation between chromosome 9 and chromosome 22) is present in >95% of cases and produces hyperactivated abl-driven protein signaling.