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Luster received a B.S, from Duke University in 1981, a PhD from Rockefeller University in 1987, and a MD from Cornell University Medical College in 1988, He had a clinical residency at Massachusetts General Hospital, and a postdoctoral training at Harvard Medical School.
Kirby served as a professor of psychiatry at several medical schools in New York: from 1914 to1919, he was Adjunct Professor of Mental Diseases at New York University and Bellevue Medical College; from 1917 to 1932, he was professor of psychiatry at Cornell University Medical College; and from 1927 to 1932 he was professor of psychiatry at the College of Physicians and Surgeons at Columbia University.