The United States Drug Enforcement Administration designated sodium hypophosphite as a List I chemical under 21 CFR 1310.02 effective November 17, 2001, specifically mentioning the compound together with several other salts of hypophosphorous acid.
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On account of its relation to the MDxx chemical class, MDP2P, as well as safrole and isosafrole, are in the United States (U.S.) Drug Enforcement Administration (DEA) List I of Chemicals of the Controlled Substances Act (CSA) via the Chemical Diversion and Trafficking Act (CDTA).
In the US sulfuric acid is included in List II of the list of essential or precursor chemicals established pursuant to the Chemical Diversion and Trafficking Act.