Maintenance of the highway was turned over to local jurisdictions in 1998, after a new, controlled-access bypass carrying US 65 opened nearby and after the bridge over the Des Moines River was removed.
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The first white settlers arrived in 1835 led by Nathan Boone, youngest son of Daniel Boone who acting on instructions from Stephen W. Kearny selected it to be the first site of Fort Des Moines on a high ridge between what Skunk River and Des Moines River.
The American paddlefish (Polyodon spathula) is currently known from the Mississippi River watershed in the United States, including slow-flowing waters of the Mississippi River itself, as well as various tributaries including the Missouri River, Ohio River, Yellowstone River, Wisconsin River, Des Moines River, and Arkansas River systems.
From the north bank of the river opposite Kaw Point in what is today Kansas City Downtown Airport he was instructed to survey a line 100 miles straight north and then east to the Des Moines River (the Sac and Fox owned the land east of the river).