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Duke Adolf Friedrich IV of Mecklenburg (5 May 1738 – 2 June 1794); succeeded his half-uncle as reigning duke with the style Ducal Serene Highness.
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Father of Louise of Mecklenburg-Strelitz; succeeded his older brother as reigning duke with the style Ducal Serene Highness, until 28 June 1815, when Mecklenburg-Strelitz was elevated to grand ducal status, at which time Duke Charles II became Grand Duke Charles II.