It was named for Francis North, 1st Earl of Guilford, father of Frederick North, Lord North, British Prime Minister from 1770 to 1782.
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Guilford had been an eminent lawyer, Solicitor-General (1671), Attorney-General (1673), and Chief Justice of the Common Pleas (1675), and in 1679 was made a member of the Council of Thirty and, on its dissolution, of the Cabinet.
North died in Madrid on 31 October 1734, when he was succeeded in his estates and in the title of Baron North by a first cousin once removed, Francis North, 3rd Baron Guilford, the grandson of North's uncle Lord Chancellor North.