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To the south of Giubiasco station, the Gotthard railway's main line commences its climb over the Monte Ceneri Pass, leaving the valley of the Ticino river that it has followed since it left the Gotthard Tunnel, and heading for Lake Lugano.
After a large number of serious accidents, in Austria (Tauern Road Tunnel, 29 May 1999, as well as in other countries, (Mont Blanc Tunnel, 24 March 1999, Gotthard Tunnel, 24 October 2001), the Austrian government expressed its concerns about the safety in tunnels, not only in road tunnels, but also in railway tunnels, considering the large amounts of dangerous goods being transported through them.
At Flüelen station, passengers transfer to an SBB train, which takes the Gotthard line up the Reuss Valley and through the Gotthard Tunnel.