Peticote Lane was severely affected by the Great Plague of 1665; the rich fled, and London lost a fifth of its population.
This is a very cold case; the children disappeared in 1665, the year of the Great Plague.
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Dr. Nathaniel Hodges (1629–1688), in his treatise of the Great Plague of London (Loimologia; published in 1672), had a recipe which he said was very successful, and of which this root was one of the chief ingredients.