University of North Carolina at Chapel Hill | Chapel Hill, North Carolina | One Tree Hill | One Tree Hill (TV series) | King of the Hill | Abbey Road Studios | Chapel Hill | Silk Road | Hill Street Blues | Parliament Hill | Gatling gun | Capitol Hill | Notting Hill | Top Gun | road | Cypress Hill | Broken Hill | Mill Hill Missionaries | Faith Hill | Harry Hill | Broken Hill, New South Wales | Road Rules | Abbey Road | Road to Perdition | Grange Hill | New Circle Road | Lauryn Hill | Benny Hill | road racing | Lewis gun |
She is most noted for her appearance in the 2011 film Gun Hill Road, for which she garnered an Independent Spirit Award nomination for Best Supporting Actress, and became the first openly transgender actress to be nominated for a major acting award in the United States.
In addition to Gun Hill Road, Santana has also had supporting roles in Eating Out 4: Drama Camp and Eating Out 5: The Open Weekend.