As a result of patronage by the family of Henry Stafford, 2nd Duke of Buckingham, the name of the institution was changed from Monks' Hostel to Buckingham College (the change is known to have occurred between 1472 and 1483).
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Henry Stafford, 1st Baron Stafford (18 September 1501 – 30 April 1563), who married Ursula Pole, daughter of Sir Richard Pole by his second wife, Lady Margaret Pole, Countess of Salisbury, daughter of George, Duke of Clarence and Lady Isabel Neville, daughter of Richard Neville, 16th Earl of Warwick ("Warwick, the Kingmaker").
In 1684 the 2nd Duke of Buckingham sold the house to Sir Ambrose Phillipps (a successful lawyer) for £28,000.
At the accession of Henry VIII on 21 April 1509 Stafford was imprisoned in the Tower on suspicion of treason, but was released without charge.
Affairs changed dramatically on 13 June 1483 during a council meeting at the Tower of London: Richard, supported by the Duke of Buckingham, accused Hastings and other council members, of having conspired against his life with the Woodvilles, with Hastings's mistress Jane Shore (formerly also mistress to Edward IV and Dorset), acting as a go-between.
Margaret Beaufort, Countess of Stafford (c. 1427–1474), the daughter of Edmund Beaufort, 1st Duke of Somerset (second creation) and the mother of Henry Stafford, 2nd Duke of Buckingham.