Traveling eastbound from O'Hare, the Kennedy interchanges with the eastern terminus of the Jane Addams Memorial Tollway (Interstate 90) and with the Tri-State Tollway (Interstate 294) at a complex junction just west of Illinois Route 171 (Cumberland Avenue).
Due to its proximity to O'Hare International Airport as well as major roads such as Interstates 90, 190, and 294, and Illinois Routes 72 and 171, the O'Hare neighborhood is a major business center.
Later, several Native American trails passed through the area, including the ancient trail that evolved into modern Archer Avenue (Illinois Route 171).
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It is also the junction of IL 83 (Kingery Highway) and IL 171 (Archer Avenue) which meet at Sag Bridge to cross the Calumet Sag Channel together on the eponymous bridge.
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