IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and regulatory T-cells.
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Extensive IL-10 locus remodeling is observed in monocytes upon stimulation of TLR or Fc receptor pathways.
Interleukin 10 knock out mice develop invasive adenocarcinoma in the colon.
Interleukin 3 | Interleukin 6 | Interleukin 5 | Interleukin 18 | Interleukin 17 | Interleukin 4 | Interleukin 15 | Interleukin 8 | Interleukin 32 | Interleukin 24 | Interleukin 2 | Interleukin 12 | interleukin 6 (IL-6) | Interleukin-3 receptor | Interleukin 22 | Interleukin 13 | Interleukin 12 receptor, beta 2 subunit | Interleukin 10 |