Prominent attendees included John C. Calhoun, Clement C. Clay, Sr., John Bell, William Gwin, and Edmund P. Gaines, but it was James Gadsden of South Carolina who was influential in the convention’s recommending a southern route for the proposed railroad, beginning in Texas and ending in San Diego or Mazatlán.
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In 1823, Colonels George Mercer Brooke and James Gadsden of the United States Army were ordered to establish a military presence on Tampa Bay in the newly acquired Florida territory to contain the Seminole Indians and curtail illegal activities along the gulf coast.