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At night, Kenny, Kyle and Stan sneak into Cartman's room and use skin bleach to make his skin pale, dye his hair red and put Henna tattoos of freckles on his face (but first they make sure he is unconscious, which Kyle makes sure of by hitting him with a small club more times than needed, due to his abject hatred of Cartman).
In a 2001 episode of South Park titled "Kenny Dies", Eric Cartman sings the song to the United States Congress to convince them to reverse a ban on stem cell research (telling them that he wanted to save his 8-year-old friend Kenny McCormick from muscular dystrophy), eventually leading members of Congress in a sing-along.
Back in South Park, Gerald goes with Stan, Kenny, and Butters to the Apple store to seek advice from "the Geniuses" on how to save Kyle.
Tsao, Cartman and Obama meet at a Red Lobster, where they are confronted by Kyle, Stan, Kenny and their friends, who learn, via explanation by Morgan Freeman, that in exchange for Obama's re-election, the Chinese want Obama to give them the rights to the Star Wars franchise (which George Lucas recently sold to the Walt Disney Company), so that the Chinese can make future Star Wars sequels.