Since the instruments are complex in design and difficult to manufacture to clinical standards, only a few manufacturers exist: Topcon, Zeiss, Canon, Nidek, Kowa, CSO and CenterVue.
Tofogliflozin (USAN, codenamed CSG452) is an experimental drug for the treatment of diabetes mellitus and is being developed by Chugai Pharma in collaboration with Kowa and Sanofi.