To a large degree, anterograde amnesia remains a mysterious ailment because the precise mechanism of storing memories is not yet well understood, although it is known that the regions involved are certain sites in the temporal cortex, especially in the hippocampus and nearby subcortical regions.
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Psycho-Physiological Interactions or PPI is a brain imaging method of estimating the effective connectivity, or functional coupling, between a brain region and the rest of the brain with relation to the performance of a particular psychological task.