In 1304–1330 under the Zaccaria family, and, after a Byzantine interlude, from 1346 and until the Ottoman conquest in 1566 under the Maona di Chio e di Focea company.
A possession of the Genoese Maona company since 1346, Chios (and its attendant islets of Psara and Oinousses) was conquered without resistance by the Ottoman Empire in 1566, as a recompense for the failure to capture Malta the previous year, and annexed as a sanjak of the Eyalet of the Archipelago.