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The Great Lakes is home to the globally significant, Ramsar Convention listed Myall Lakes wetlands.
The mountain stream tree frog, (Litoria barringtonensis) is a species of tree frog native to highland areas of NSW, Australia stretching from the Myall Lakes area, north to around Dorrigo National Park and west to Barrington Tops National Park.
After flowing past the town of Bulahdelah, east of the small settlement of Nerong, the Myall River enters the most southern of the three Ramsar-protected Myall Lakes, Bombah Broadwater, within the Myall Lakes National Park.