Highway 180 is designated as part of the Trail of Tears National Historic Trail as well as Arkansas Heritage Trails designations as the Butterfield Trail, Trail of Tears (Benge Route), and Civil War Trails (Herron's Approach).
LA 6 is also steeped in history, as it roughly follows the El Camino Real de los Tejas, a National Historic Trail, and passes through Natchitoches, the oldest permanent settlement in the Louisiana Purchase.
National Football League | National Register of Historic Places | National Hockey League | England national football team | National Basketball Association | National Science Foundation | National Geographic | National Trust | National Endowment for the Arts | National Geographic Society | Argentina national football team | National Trust for Places of Historic Interest or Natural Beauty | National Park Service | National League | Australian National University | National Guard | National Geographic Channel | National Institutes of Health | National Guard of the United States | National Collegiate Athletic Association | United States National Research Council | National Portrait Gallery | National Academy of Sciences | Indian National Congress | United States men's national soccer team | National Research Council | Royal National Theatre | National Gallery of Art | Mexico national football team | National University of Singapore |
Remnants of the trail in Kansas, Nebraska, Wyoming, Idaho, and Oregon have been listed on the National Register of Historic Places, and the entire trail is a designated National Historic Trail (listed as the Oregon National Historic Trail).