Guckenheimer studies dynamical models of a small neural system, the stomatogastric ganglion of crustaceans - attempting to learn more about neuromodulation, the ways in which the rhythmic output of the STG is modified by chemical and electrical inputs.
Pulsed radiofrequency, neuromodulation, direct introduction of medication and nerve ablation may be used to target either the tissue structures and organ/systems responsible for persistent nociception or the nociceptors from the structures implicated as the source of chronic pain.
Spinal cord stimulators for intractable pain (under subsidiary "Advanced Neuromodulation System" based in Plano, Texas)