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Several male characters, including Cassius and Octavius Caesar, are played as women, in order to reflect the existence today of female politicians such as Angela Merkel and Hillary Clinton.
A good example is the line spoken by Cleopatra in act five of Antony and Cleopatra (1607), when she contemplates her humiliation in Rome at the hands of Octavius Caesar; she imagines mocking theatrical renditions of her own story: "And I shall see some squeaking Cleopatra boy my greatness in the posture of a whore" (5.2.215-217).