George Mathews (1739–1812) - Revolutionary hero and twice Governor
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Meriwether Lewis (1774–1809) was a teenage resident and later the leader of the Lewis and Clark Expedition
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William Hutchinson Norris (September 25, 1800 in Oglethorpe County, Georgia – July 13, 1893 in Santa Bárbara d'Oeste, São Paulo) is known for being a founder of the town of Americana and a settlement in Santa Bárbara d'Oeste, and a significant figure in the history of the Confederados.