Located at the intersection of State Route 335, Lucasville-Minford Road and Bennett Road, it lies just north of the unincorporated community of Minford, 7 miles (11½ km) east of the census-designated place of Lucasville, and 14 miles (23 km) northeast of the city of Portsmouth, the county seat of Scioto County.
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The locations of the interchanges are: U.S. Route 52 between New Boston and Wheelersburg, State Route 140 near the Portsmouth city limit, Airport Road adjacent to the Greater Portsmouth Regional Airport / Access to Ohio State Route 335 just south of Minford, at Lucasville-Minford Road / County Route 28 near Rases Mountain Drive in Minford, and at U.S. 23 just north of Lucasville.