Four National Parks can be accessed on the highway, Grand Canyon National Park, Petrified Forest National Park, Guadalupe Mountains National Park, and Carlsbad Caverns National Park.
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Shortly after following South Navajo Boulevard, however, US 180 follows a South-Southeast route, running by the Petrified Forest National Park and continuing South-Southeast to and through a small branch of the Zuni Indian Reservation, to St. Johns, Apache County, Arizona where it meets U.S. Route 191.
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