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Lutz was the first Latin American scientist to study in depth and to confirm the mechanisms of transmission of yellow fever by the Aedes aegypti species of mosquitoes, its natural reservoir and vector, as they had been discovered a few years before, by American physician Walter Reed.
The operation was a field test designed to determine the feasibility of producing, storing, loading into munitions, and dispersing from aircraft the yellow fever mosquito (though these were not infected for the test) (Aedes aegypti).