The bridge of five arches constructed by Taddeo Gaddi was destroyed in the flood of 1557, which occasioned Ammanati's replacement.
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After the creation of the Grand Duchy of Tuscany in the 16th century, via de' Tornabuoni was the seat of the processions from Palazzo Pitti to via Maggio and Ponte Santa Trinità, as well as pallone col bracciale matches, Calcio Fiorentino games and horse races.