The first ligands to be discovered were synthetic and members of the halogenated aromatic hydrocarbons (polychlorinated dibenzodioxins, dibenzofurans and biphenyls) and polycyclic aromatic hydrocarbons (3-methylcholanthrene, benzo(a)pyrene, benzanthracenes and benzoflavones).
Especially the mechanism of action of benzo(a)pyrene-related DNA modification is well investigated and relates to the activity of cytochrome P450 subclass 1A1 (CYP1A1).
::This article is about a subject of plant anatomy;
For 'Pyrene', or other uses of 'Pyrena', see Pyrene (disambiguation);
For 'Pirene', see Pirene.
In the ancient past, Hercules visited the area, and fell in love with a beautiful girl named Pyrene, who happened to be a daughter of the King of Cerdagne.
The liner Queen Mary was protected by the installation of a Pyrene foam fire-fighting system in 1933.