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Binondo is also considered a historic centre of the mestizo de sangley community; famous residents include St. Lorenzo Ruiz, the Filipino protomartyr, and Venerable Mother Ignacia del Espiritu Santo, founder of the Congregation of the Religious of the Virgin Mary.
In 1870, the reconstruction began when a temporary house of worship, the “Provincial”, along Año 1733 street, emerged as a narrow, and simple edifice which was later used by the RVM Sisters of the Colegio de la Sagrada Familia (now St. Mary's College of Baliuag) as classroom.