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Lupasco was one of the founding members of the International Center for Transdisciplinary Research (Centre International de Recherches et Etudes Transdisciplinaires (CIRET)), founded in Paris in 1987 by Basarab Nicolescu, Edgar Morin, René Berger, Michel Random and other key figures of the French intelligentsia.
In addition, he is the co-founder, with René Berger, of the Study Group on Transdisciplinarity at UNESCO (1992) and the founder and Director of the "Transdisciplinarity" Series, Rocher Editions, Monaco and of the "Romanians of Paris", Piktos/Oxus Editions, Paris.