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The school is named after the area's first seigneur and French explorer Robert René Cavelier de La Salle (born at Rouen, France in 1643, died in Texas in 1687).
An expedition led by the French explorer René Robert Cavelier, Sieur de La Salle named it Lac Sainte-Claire, because they entered the lake on August 12, 1679, the feast day of Saint Clare of Assisi.