The Quesnel River supports a number of fish species, the most significant of which are Sockeye salmon (Oncorhynchus nerka), Rainbow trout (Oncorhynchus mykiss), Largescale sucker (Catostomus macrocheilus), Longnose sucker (Catostomus catostomus), Redside shiner (Richardsonius balteatus), Northern pikeminnow (Ptychocheilus oregonensis), Peamouth chub (Mylocheilus caurinus), and Lake chub (Couesius plumbeus).