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The manor house of the Lord of the Manor, in the centre of the medieval town of Manchester, stood on a sandstone bluff, at the confluence of the River Irwell and the River Irk.
Clifton Aqueduct, built in 1796, carried the Manchester, Bolton and Bury Canal across the River Irwell in Clifton, Salford, England.
Between 1752 and 1756, James Brindley devised a method of pumping water from the nearby Wet Earth Colliery using power harnessed from the River Irwell via a water wheel.
The main approach road ran from the end of Deansgate near Manchester Cathedral, passing above the River Irwell and Chapel Street; a second approach road led up from Blackfriars Road.
A bridge between Chapel Street in Salford and Hunts Bank in Manchester was first proposed in 1858, as a means of improving road links between Salford and Manchester Victoria station, each separated by the River Irwell.
Manchester city centre is "traditionally defined as being within the boundaries of Market Street, the River Irwell, Peter Street and Portland Street, including Piccadilly".
The River Irwell Railway Bridge, is a stone railway bridge of 1830 by George Stephenson near Water Street in Manchester, England.