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As a distinctive but inoffensive exclamation, it has been widely used as a catchphrase in popular fiction, including the works of Mark Twain, the Rathbone–Bruce Sherlock Holmes films (said by Dr. Watson), Silver Age comics (especially Superman), the Rocky Horror Picture Show, and the Back to the Future films (Dr. Emmett Brown).
On the Rocky Horror Picture Show DVD commentary with Richard O'Brien (Riff-Raff) and Patricia Quinn (Magenta), O'Brien confessed being extremely nervous during the opening of the Rocky Horror Show.
Shock Treatment, the 1981 follow up to The Rocky Horror Picture Show