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The first settlement in what is today the municipality of Doctor González took place in October 21, 1694, founded by Spanish settlers as Hacienda de Ramos, the history of the region where the municipality is now located lies within the Salinas Valley, a historic region in the former New Kingdom of León which extended throughout the Salinas River comprising several municipalities in northern Nuevo León, an important region during the colonization of Nuevo León.
With the highest temperature tolerance among the native fish of the Central Valley, they can be found in both warm and cool water; they also have considerable salt tolerance, for instance occurring in Suisun Marsh (7-8 ppt salinity), and Salinas River lagoon (9 ppt).
The Sacramento perch (Archoplites interruptus) is a sunfish (family Centrarchidae) native to the Sacramento–San Joaquin, Pajaro, and Salinas River areas in California, but widely introduced throughout the western United States.
US-101 runs in a North-South direction and bisects the city (along with the Salinas River), into the western and eastern portions of the city.
The Salinan people were named after the Salinas River by Robert Latham (needs documentation)(1856) and John Powell (1891).