Mosley was born in Staffordshire in 1848 the eldest son of Sir Tonman Mosley, 3rd Baronet, of Ancoats (9 July 1813 – 28 April 1890), who succeeded to the title of 3rd Baronet Mosley, of Ancoats, on 24 May 1871, and wife Catherine Wood (died 22 April 1891), daughter of The Reverend John Wood of Swanwick, Derbyshire.
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Mosley was nicknamed "Baronet John Bull" due to his resemblance to John Bull, the national personification of Great Britain.
Sir | Sir Walter Scott | Sir Arthur Conan Doyle | Oswald Mosley | Sir Robert Peel | Lee Harvey Oswald | Oswald the Lucky Rabbit | Sir Arthur Harris, 1st Baronet | Richard Oswald | Sir Raylton Dixon | Sir Harold Hillier Gardens | Sir Fitzroy Maclean, 1st Baronet | Sir Francis Baring, 1st Baronet | Oswald Spengler | Max Mosley | Sir William Temple, 1st Baronet | Shane Mosley | Sir Richard Fanshawe, 1st Baronet | Oswald Wynd | Sir William Johnson, 1st Baronet | Sir Robert Eden, 1st Baronet, of Maryland | Sir Orlando Bridgeman, 1st Baronet, of Great Lever | Sir Nigel | Sir John D'Oyly, 1st Baronet, of Kandy | Sir James Fergusson, 6th Baronet | Sir Henry Rawlinson, 1st Baronet | Sir Henry Rawlinson | Sir Frederick Pollock, 3rd Baronet | Sir Douglas Quintet | Sir Charles Trevelyan, 1st Baronet |
In 1993, he appeared in Remains of the Day as Sir Geoffrey Wren, a character based on the 1930s British fascist Sir Oswald Mosley.