The Cotton Baronetcy, of Conington in the County of Huntingdon, was created in the Baronetage of England on 29 June 1611 for the antiquary Robert Cotton, who also represented five constituencies in the House of Commons.
He had previously inherited the baronetcy, of Combermere in the County Palatine of Chester, that was created in the Baronetage of England on 29 March 1677 for his great-great-grandfather Robert Cotton.
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To Clare Hall Library he bequeathed all his Greek manuscripts and some Greek books; to Sir Robert Cotton he left a manuscript history of Ely Cathedral in Latin.
It is not known where the manuscript was between the 13th century and 1638, when it appears in a catalogue of the collection formed by the antiquary Sir Robert Cotton between about 1588 and 1629, and added to by his son and grandson.