The district contains the Astore Valley and is bounded to the west by Diamer District (from which is was separated in 2004), to the north by Gilgit District, to the east by Skardu District and to the south by Khyber-Pakhtunkhwa and Neelum District of Azad Kashmir.
Many of the highest peaks in Gilgit–Baltistan, such as Baltoro Muztagh, K2 (Mount Godwin-Austen) (8,611 m), the second-highest mountain in the world), the Gasherbrums (7,932 - 8,080 meters, ranked 12-17 in the world), and Masherbrum (7,821 m), 22nd-highest in the world), lie in the Skardu District.
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Northeast is Aksai Chin, (China), to the north and northwest is the Skardu District, to the west is the Astore District, and to the south is the Indian state of Jammu and Kashmir.
Indus River - enters Gilgit District from Skardu District about six kilometers north of Jaglot where Gilgit River falls into Indus River and the Indus flows south along the Karakoram Highway.
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