The term originated between 1890 and 1895 as a calque from the French phrase tranche de vie, credited to the French playwright Jean Jullien (1854–1919).
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Chancellor was educated at Tonbridge School in Kent, England, where he was the bass player for a school band named Slice of Life and used to perform a cover version of Corey Hart's Sunglasses at Night in the dining room of his boarding house.
Tyler's short slice-of-life stories and her distinctive artwork brought her critical attention as one of a growing number of female artists shaping the direction of underground/alternative comics in North America in the 1980s; she appeared in the influential feminist anthologies Wimmen's Comix and Twisted Sisters.
In 1997 Knudsen debuted in the lead role of Julie in Jonas Elmer's slice-of-life comedy Let's Get Lost.