Digby's father was Johnathan Denniss (1700–1736) (or Dennis) a factor of the South Sea Company, later of Kingston, Jamaica, born in the parish of St. Helens, Bishopsgate, London.
As a Member of Parliament Jekyll helped draft many bills, and was key in convincing the government to investigate the collapse of the South Sea Company in 1720.
Meares' vision required a loosening of the monopolistic power of the East India Company and the South Sea Company, which between them controlled all British trade in the Pacific.
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The Crowley Iron Works at Winlaton, Winlaton Mill, and at Swalwell, all in County Durham were probably, at the time, Europe's biggest industrial location and later, as he was owed so much money by the British Government, Ambrose became a director of the South Sea Company on its formation.
In 1771 Angerstein married Anna Crockett (widow of Charles Crockett and daughter of Henry Muilman (1700–1772) a South Sea Company director, banker, Danish consul in London and Russia Company consul, and Anne née Darnall) at St Peter-le-Poer, Old Broad Street.
His property Included estates in Exhall and Bedworth, Warwickshire; in Wheathamstead, Hertfordshire; and in the city of London; besides stock and annuities in the South Sea Company.
Sophia received many gifts from those seeking patronage; e.g. between 1715 and 1720, she received £9,545 from the Duke of Chandos and 1720, was given £15,000 of stock by the South Sea Company, with a bonus of £120 for every point the stock rose above £154.