Dupuytren is mentioned as a youthful acquaintance of Stephen Maturin in The Surgeon's Mate by Patrick O'Brian.
It is at a disappointing London performance of Le astuzie feminili that Stephen Maturin glimpses Diana Villiers, now a kept woman, in Patrick O'Brian's historical novel Post Captain.
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The series focuses on two main characters, naval officer Jack Aubrey and physician, naturalist, and spy Stephen Maturin, and the ongoing plot is structured around Aubrey's ascent from Lieutenant to Rear Admiral in the Royal Navy during the French Revolutionary and Napoleonic Wars.