In the following years, Silbermann was involved in several major commissions, including constructing an organ at Strasbourg Cathedral (1714-1716), which was the largest organ he built during his career.
Similar devices have been used in early churches, and some were discovered in the vaulted ceiling of the choir of Strasbourg Cathedral, and in mosques dating back to the 11th century.
He died of the plague at Speyer and was buried in Strasbourg Cathedral.
He was ordained to the priesthood on 1 September 1844, and then preached with much success in the Strasbourg Cathedral, until the year 1849.
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He was largely engaged in mural paintings for churches, and specimens of his art will be found in the Abbey of St. Denis, in St. Paul at Nîmes, St. Polycarp at Lyons, the Oratory at Birmingham, the Church of the Celestines at Avignon, and in Strassburg Cathedral.
Pleyel was brought before the Committee of Public Safety a total of seven times due to the following: his foreign status, his recent purchase of a château, and his ties with the Strasbourg Cathedral.