When the Stratton brothers were brought to trial, MacNaghten, Collins, and Richard Muir, the prosecutor for the Crown, knew that they would face an uphill battle.
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When Henry was appointed Commissioner in 1903, succeeding Sir Edward Bradford, Macnaghten was appointed Assistant Commissioner (Crime) and became involved in many of the most famous cases in the history of the Metropolitan Police, including the Hawley Harvey Crippen case and the Farrow double murder case, which resulted in the conviction and hanging of the Albert and Alfred Stratton largely on the basis on fingerprint evidence.